StressCovidV1, Main, Exploration, bibRecord, 002D21

Prenatal rubella, premorbid abnormalities, and adult schizophrenia

Identifieur interne : 002D21 ( Main/Exploration ); précédent : 002D20; suivant : 002D22

Prenatal rubella, premorbid abnormalities, and adult schizophrenia

Auteurs : Alan S. Brown [États-Unis] ; Patricia Cohen [États-Unis] ; Jill Harkavy-Friedman [États-Unis] ; Vicki Babulas [États-Unis] ; Dolores Malaspina [États-Unis] ; Jack M. Gorman [États-Unis] ; Ezra S. Susser [États-Unis]

Source :

Biological Psychiatry [ 0006-3223 ] ; 2001.

RBID : ISTEX:6862CA286600D7D0604B8F9F785BD722F8D9ED35

English descriptors

Abstract

Abstract: Background: Premorbid neurocognitive, neuromotor, and behavioral function tends to be disturbed in schizophrenia. We previously demonstrated that a birth cohort clinically and serologically documented with prenatal rubella evidenced a marked increase in risk of nonaffective psychosis. In our study, we examined whether rubella-exposed subjects destined to develop schizophrenia and other schizophrenia spectrum disorders (SSD), compared with exposed control subjects, had greater impairment in several premorbid functions.Methods: Subjects were interviewed using a direct, comprehensive research assessment and diagnosed by consensus. We compared the degree of IQ decline, as well as premorbid neuromotor and behavioral dysfunction, between rubella-exposed subjects who developed schizophrenia spectrum psychosis (SSP) and exposed control subjects from the cohort. We also compared the gestational timing of rubella infection between the cases and control subjects.Results: This rubella-exposed birth cohort evidenced a markedly increased risk of SSD (20.4% or 11/53). Rubella-exposed SSP cases, compared with rubella-exposed control subjects, demonstrated a decline in IQ from childhood to adolescence, and increased premorbid neuromotor and behavioral abnormalities. Moreover, it appears that early gestational rubella exposure may represent a period of increased vulnerability for SSD.Conclusions: These findings link a known prenatal exposure, a deviant neurodevelopmental trajectory in childhood and adolescence, and SSP in adulthood within the same individuals.

Url:

https://api.istex.fr/ark:/67375/6H6-12NCK3D4-M/fulltext.pdf

DOI: 10.1016/S0006-3223(01)01068-X

Affiliations:

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Le document en format XML

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<term>Biol psychiatry</term>
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<term>Congenital rubella</term>
<term>Congenital rubella syndrome</term>
<term>Control group</term>
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<term>Neuromotor dysfunction</term>
<term>Neuronal density</term>
<term>Nonaffective</term>
<term>Nonaffective psychosis</term>
<term>Other schizophrenia spectrum disorders</term>
<term>Pathogenesis</term>
<term>Pathogenic mechanisms</term>
<term>Population estimates</term>
<term>Prefrontal</term>
<term>Prefrontal cortex</term>
<term>Premorbid</term>
<term>Premorbid abnormalities</term>
<term>Premorbid anomalies</term>
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<term>Prenatal</term>
<term>Prenatal exposure</term>
<term>Prenatal rubella</term>
<term>Present study</term>
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<term>Psychotic disorder</term>
<term>Rbdep</term>
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<term>Rubellaexposed subjects</term>
<term>Schizophrenia</term>
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<term>Susser</term>
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<term>Synaptic density</term>
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<term>Unexposed</term>
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<front><div type="abstract" xml:lang="en">Abstract: Background: Premorbid neurocognitive, neuromotor, and behavioral function tends to be disturbed in schizophrenia. We previously demonstrated that a birth cohort clinically and serologically documented with prenatal rubella evidenced a marked increase in risk of nonaffective psychosis. In our study, we examined whether rubella-exposed subjects destined to develop schizophrenia and other schizophrenia spectrum disorders (SSD), compared with exposed control subjects, had greater impairment in several premorbid functions.Methods: Subjects were interviewed using a direct, comprehensive research assessment and diagnosed by consensus. We compared the degree of IQ decline, as well as premorbid neuromotor and behavioral dysfunction, between rubella-exposed subjects who developed schizophrenia spectrum psychosis (SSP) and exposed control subjects from the cohort. We also compared the gestational timing of rubella infection between the cases and control subjects.Results: This rubella-exposed birth cohort evidenced a markedly increased risk of SSD (20.4% or 11/53). Rubella-exposed SSP cases, compared with rubella-exposed control subjects, demonstrated a decline in IQ from childhood to adolescence, and increased premorbid neuromotor and behavioral abnormalities. Moreover, it appears that early gestational rubella exposure may represent a period of increased vulnerability for SSD.Conclusions: These findings link a known prenatal exposure, a deviant neurodevelopmental trajectory in childhood and adolescence, and SSP in adulthood within the same individuals.</div>
</front>
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Prenatal rubella, premorbid abnormalities, and adult schizophrenia

Prenatal rubella, premorbid abnormalities, and adult schizophrenia

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Abstract

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